An Edge interview with Grasshopper CEO Goichi Suda has recently been reprinted by NextGen, and features a few insights into Suda51's development of No More Heroes, as well as the punk-rock designer's future plans.
Regarding the Wii, Suda51 felt that No More Heroes was a unique opportunity to appeal to the wide user base for the console, and set out to make the title appeal to both hardcore gamers, and those that might be experiencing their first action game.
Beyond No More Heroes, Suda51 expresses interest in developing for the Xbox 360, citing the console's tremendous performance in the States. According to Suda, America is the "Major League" of game development, and it's a market he'd most definitely like to conquer. We'll just have to wait and see what his crazy brain cooks up next.