DJ Hero was the number one new intellectual property by revenue in the US and Europe during 2009, according to publisher Activision and the NPD Group.
The game and peripheral launched at a price of around £100 in the UK and around $120 in the US, and is the latest in the publisher's high-priced game releases.
"DJ Hero has transformed music gaming by marrying an innovative turntable controller and exhilarating gameplay with the biggest artists and incredible music from around the world," said Robert Kotick, CEO of Activision Blizzard.
"Consumers and critics agree that DJ Hero is one of the best music games ever created and further establishes Guitar Hero as the premier franchise of its kind."
The publisher is expected to detail sequel plans for DJ Hero this year. The amount of additional music for the game released as downloadable content has not been as prolific as for the Guitar Hero games, in part due to a more complicated licensing structure.